Regulatory T Cells Contribute to Allergen Tolerance Induced by Daily Airway Immunostimulant Exposures
نویسندگان
چکیده
منابع مشابه
Attenuation of allergen-induced airway hyperresponsiveness is mediated by airway regulatory T cells.
Understanding the mechanisms involved in respiratory tolerance to inhaled allergens could potentially result in improved therapies for asthma and allergic diseases. Airway hyperresponsiveness (AHR) is a major feature of allergic asthma, thus the aim of the current study was to investigate mechanisms underlying suppression of allergen-induced AHR during chronic allergen exposure. Adult BALB/c mi...
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Thymus-derived, naturally occurring CD4(+)CD25(+)Foxp3(+) regulatory T cells (nTregs) and Tregs induced in the periphery (iTregs) have both been implicated in regulating immune responses. However, the relationship between these populations in the same host, and their relative contribution to the overall Treg pool, has not been examined. Using a tumor-induced T cell tolerance model, we find that...
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© Copyright The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://e-aair.org Dr. Ralph M. Steinman, who discovered the dendritic cells (DCs) that play a key role in the adaptive immune response, was awarded the 2011 Nobel Prize in Physiology or Medicine 3 days after his untimely death. Dr. Steinman used autologous ...
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ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2011
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2010-0001oc